How cholinergic modulation changes cortical circuits

Nature: A synaptic memory trace for cortical receptive field plasticity
Froemke RC, Merzenich MM, Schreiner CE

This is an excellent paper revealing how cholinergic modulation (by stimulating nucleus basalis, or basal forebrain) transiently changes the balance between excitation and inhibition within the cortical circuit, thus mediating specific circuit plasticity in the primary auditory cortex…

Full post in SCLin’s Neuroscience blog.

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